HPB P41 Pitfalls in establishing a preoperative diagnosis; correlating the radiological and histopathological findings of suspected intraductal papillary neoplasm of the bile duct (IPNB)

Abstract Background Intraductal papillary neoplasm of the bile duct (IPNB) represents a cohort uncommon biliary tract tumours. It is commonly unrecognised or misdiagnosed in cross sectional imaging liver. This rare tumour significant clinical importance as it serves pre-cursor lesion for Cholangiocarcinoma. The diagnostic work up patient with suspected IPNB remains predominantly based on and yet no consensus has been achieved regarding optimal algorithm. aim this study was to compare radiological clinico-pathological features patients confirmed managed single tertiary center. Methods Retrospective review departmental database consecutive performed. Clinical information demographics, disease presentation, characteristics histo-pathological analysed. Results Eighteen were noted, which histological confirmation present eight cases (62%). most frequent presentation an incidental finding (50%). diagnosis made following MRI 63% cases. Invasive adenocarcinoma five (63%). In remaining three patients, low grade dysplasia noted within their Conclusions frequently associated concurrent invasive malignancy. Observation alone insufficient. Radiological assessment these tumours fundamental investigation diagnosis. However, without confirmatory histology perioperatively, cannot be assured therefore decision management must upon patient-centered discussion careful evaluation risk.